Firazyr (icatibant) is a brand-name subcutaneous injection prescribed for the treatment of hereditary angioedema (HAE). Like other medications, Firazyr may cause side effects, ranging from mild to serious. If you experience any side effects that are bothersome or persistent, consult your doctor or pharmacist for guidance.
Common Side Effects of Firazyr
Firazyr can cause certain side effects, some of which are more common than others. These effects are often temporary, lasting a few days to weeks. However, if they persist or worsen, medical advice is recommended.
More Common Side Effects
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- Fever
- Dizziness
- Skin rash
- Injection site reactions (see details below)
Mild Side Effects
Mild side effects of Firazyr may include:
- Nausea
- Headache
- Increased transaminase levels (a sign of liver enzyme changes)
- Injection site reactions
If any of these side effects become difficult to tolerate, speak with your healthcare provider about possible management strategies or alternative treatments.
Serious Side Effects of Firazyr
No serious side effects were reported in clinical trials. However, if you develop any concerning symptoms while taking Firazyr, contact your doctor immediately. In the case of a medical emergency, call 911 or your local emergency number.
Detailed Overview of Side Effects
Injection Site Reactions
Injection site reactions are the most commonly reported side effect. These reactions occur at the area where Firazyr is injected (typically under the skin below the belly button on either side).
Symptoms include:
- Pain and warmth
- Itchiness
- Bruising (including hematoma)
- Redness or other skin discoloration
- Rash or hives
- Swelling
Management: To relieve symptoms, your doctor may recommend applying a cold compress or using pain relievers. Always consult your healthcare provider before taking any additional medications to manage side effects.
Increased Transaminase Levels
Firazyr may lead to an increase in transaminase levels, which are enzymes found in the liver. While this is not a common side effect and no liver problems were reported in studies, monitoring may be required.
Management: Your doctor may conduct liver function tests, especially if you use Firazyr regularly. If enzyme levels are elevated, further evaluation may be needed to determine the cause.
Allergic Reactions
Although allergic reactions were not reported in Firazyr clinical trials, they remain a potential risk.
Symptoms of an allergic reaction may include:
- Mild symptoms: Rash or itching
- Severe symptoms: Swelling, difficulty breathing
Management:
- For mild symptoms, contact your doctor for advice on symptom management.
- For severe reactions, call 911 or your local emergency number immediately, as these can be life-threatening. If you have had a previous severe allergic reaction to Firazyr, your doctor may suggest an alternative treatment.
Precautions for Firazyr
Before starting Firazyr, discuss your health history with your doctor. The medication may not be suitable if you have:
- A history of allergic reactions to Firazyr or similar drugs
- Pregnancy or are planning to become pregnant
- Breastfeeding
Reporting Side Effects The FDA continues to track and review medication side effects. If you experience side effects while taking Firazyr and want to report them, visit the MedWatch website.
Disclaimer: Medical News Today has made every effort to ensure the accuracy and completeness of this information. However, this article should not replace professional medical advice. Always consult a healthcare provider before taking any medication. The absence of specific warnings does not imply that Firazyr is suitable for all patients or uses.
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